The Paton Welding Journal, 2025, №05

2025 №05 (02)

DOI of Article 10.37434/tpwj2025.05.03

2025 №05 (04)

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The Paton Welding Journal, 2025, #5, 30-37 pages

Synthesis and study of a pharmaceutical composition with silver nanoparticles, produced by electron beam evaporation

G.G. Didikin

E.O. Paton Electric Welding Institute of the NASU. 11 Kazymyr Malevych Str., 03150, Kyiv, Ukraine. E-mail: didikin@paton-icebt.kiev.ua

Abstract
A technological scheme for generating and forming a directed atomic and molecular flow of silver in the process of electron beam evaporation and condensation for the synthesis of nanocomposites is considered. The influence of the initial mass of silver, beam current, evaporation time, and evaporation rate on the mass of evaporated silver was evaluated. The distribution of the average size of silver nanoparticles depending on the evaporated silver velocity was estimated. The obtained results make it possible to synthesize nanocomposites with a predetermined most probable average size of silver nanoparticles. The structure of the PVP–Ag composite and of the H2O–PVP–Ag and Ethanol–PVP–Ag colloidal systems was investigated by TEM and photon correlation spectroscopy (PCS). The results of the study of glucosamine substance with PVP and nanosilver in the form of a gel with antimicrobial (antistaphylococcal, antipseudomonal), wound healing and antiinflammatory effects, which has low toxicity and can be used for the local treatment of infected wounds and purulent inflammatory skin lesions, are presented.
Keywords: composite powders, nanostructured coatings, electron beam evaporation and condensation (EB–PVD), evaporator design, directed vapor flow in vacuum, deposition, colloidal systems, polyvinylpyrrolidone, photon correlation spectroscopy

Received: 22.01.2025
Received in revised form: 19.03.2025
Accepted: 30.05.2025

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Suggested Citation

G.G. Didikin (2025) Synthesis and study of a pharmaceutical composition with silver nanoparticles, produced by electron beam evaporation. The Paton Welding J., 05, 30-37.

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